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Anavex Life Sciences, AVXL, Profile, Summary
Anavex Life Sciences |AVXL | Profile
Anavex Life Sciences Corp. is a biopharmaceutical company engaged in the discovery and development of new drugs for the treatment of neurological diseases and cancer, utilizing its proprietary drug discovery SIGMACEPTOR™ platform. The Anavex portfolio comprises novel, wholly owned sigma receptor agonists and antagonists. The company’s lead drug candidate for Alzheimer’s Disease (AD), ANAVEX 2-73, has successfully completed a Phase 1 single ascending dose (SAD) clinical trial. The company has also started scale-up manufacturing for ANAVEX 1-41, its second lead compound, targeting depression and AD. With sufficient quantities of ANAVEX 1-41 in hand, the company will be in a position to advance the program and begin preclinical studies on large animals in the near term.
Neurological diseases (CNS): Anavex SIGMACEPTOR™-N program involves the discovery and development of original drug candidates, targeting neurological diseases such as Alzheimer’s disease, epilepsy, and depression. The company’s lead drug candidates exhibit high affinity and selectivity to sigma receptors and also synergistic action with other receptors, such as Muscarinic and NMDA, with strong evidence of anti-amnesic, neuroprotective, and anxiolytic properties.
Oncology: Anavex SIGMACEPTOR™-C program involves the discovery and development of original drug candidates targeting cancer. The company’s lead drug candidates exhibit high affinity to sigma receptors with strong evidence for selective apoptosis of cancerous cells, without affecting healthy cells, anti-metastatic and low toxicity properties in various types of cancer such as melanoma, prostate and pancreas, and neuropathic pain.
In addition, several series of sigma ligands currently at different stages of development, target stroke, diabetes, multiple sclerosis and Parkinson’s disease.
The Pipe Line
Anavex’s lead drug candidate ANAVEX 2-73 -targeting Alzheimer’s Disease- is in Phase 1 clinical trials. The company has also initiated scale-up manufacturing of ANAVEX 1-41 targeting a range of important CNS disorders, including depression and Alzheimer’s Disease. Three more of its compounds (for malignant melanoma, prostatic cancer and epilepsy) are expected to reach final preclinical stages in the near term.
Other early-stage preclinical research (see diagram) involves drug candidates that target diseases like depression, neuropathic pain and various types of cancer.
Source: Anavex, OxBridge Research, Daily Stock Deals
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FFFC, Fast Funds Financial, Profile,Life Collateralized Mortgage Obligagtions
FastFunds Financial | FFFC | Profile
FastFunds Financial Corporation is a holding company currently operates in the financial services industry segment. The company’s wholly-owned subsidiary, NET LIFE Financial Processing, Inc., has acquired the exclusive mortgage servicing rights for NET LIFE Financial Holdings (“NET LIFE”) from the holder, a Florida Trust.
NET LIFE is a development stage enterprise that has developed and is offering an innovative new mortgage product that is not based on credit history (no doc) or personal guarantees. It is only secured by the underlying collateral and a life insurance policy on the borrower. Therefore, all that is required to qualify for a mortgage loan is qualifying for a life insurance policy, a down payment that usually amounts to 10% of the purchase price and verification that the borrower has the financial ability to pay the monthly payments. NET LIFE believes this mortgage product will be attractive to a wide spectrum of potential borrowers including:
first time home buyers
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borrowers who have experienced prior financial difficulties such as foreclosures, bankruptcies, late payments or credit problems; presently employed and whose current income would qualify for a mortgage loan; but who couldn’t otherwise qualify
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borrowers who may wish to bypass the traditional paperwork involved in the typical underwriting process but who would otherwise qualify.
Innovative Mortgage Products
FastFunds Financial combined with its partner, NET LIFE, have developed an innovative new mortgage product that is not based on credit history (no doc) or personal guarantees. It is only secured by the underlying collateral and a life insurance policy on the borrower. Therefore, all that is required to qualify for a mortgage loan is qualifying for a life insurance policy, a down payment that usually amounts to 10% of the purchase price and verification that the borrower has the financial ability to pay the monthly payments. NET LIFE believes this mortgage product will be beneficial to a wide spectrum of potential borrowers including individuals and businesses.
NET LIFE LCMO
The Company believes a NET LIFE LCMO (Life Collateralized Mortgage Obligation) could substantially improve America’s banking and mortgage crisis. A NET LIFE LCMO is a residential, business or corporate real estate mortgage which is not based on credit history; only on the collateral.
All that is required for which to qualify is:
(a.) that you are healthy
(b.) that the property maintains and sustains its stated value
(c.) that you have the income to pay your mortgage.
All NET LIFE LCMO mortgages are processed, managed and serviced exactly like a conventional mortgage without all of the red-tape qualification. NET LIFE has only reinvented the “vehicle”; not the “wheel” it rides upon.
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Top 10 funniest comments from Bernanke
Ben Bernanke delivered a hilarious commencement speech to Princeton undergrads Sunday, 06/02/2013.
1) “Don’t be afraid to let the drama play out.” Nodding to Forrest Gump’s “life is like a box of chocolates,” Bernanke remarked: “Life is amazingly unpredictable; any 22-year-old who thinks they know where they will be in 10 years, much less in 30, is simply lacking imagination.”
He offered up a case study from his own life. “A dozen years ago I was minding my own business teaching Economics 101 in Alexander Hall and trying to think of good excuses for avoiding faculty meetings. Then I got a phone call…”
2) Focus on becoming a better human being: “If you are not happy with yourself, even the loftiest achievements won’t bring you much satisfaction.”
3) Those who are luckiest also have the greatest responsibility: “As the Gospel of Luke says (and I am sure my rabbi will forgive me for quoting the New Testament in a good cause): ‘From everyone to whom much has been given, much will be required; and from the one to whom much has been entrusted, even more will be demanded.”
He gave the Biblical quote an academic spin. “Kind of grading on the curve, you might say.”
4) Effort matters: “I think most of us would agree that people who have, say, little formal schooling but labor honestly and diligently to help feed, clothe, and educate their families are deserving of greater respect — and help, if necessary — than many people who are superficially more successful,” Bernanke said. “They’re more fun to have a beer with, too.”
5) Most policymakers are trying to do the right thing: “The greatest forces in Washington are ideas, and people prepared to act on those ideas. Public service isn’t easy. But, in the end, if you are inclined in that direction, it is a worthy and challenging pursuit.”
6) On economics: “Economics is a highly sophisticated field of thought that is superb at explaining to policymakers precisely why the choices they made in the past were wrong. About the future, not so much.”
7) Money isn’t everything: “I’m not going to tell you that money doesn’t matter, because you wouldn’t believe me anyway,” Bernanke quipped.
“If you are part of the lucky minority with the ability to choose, remember that money is a means, not an end.”
8) Don’t be afraid to fail: “Nobody likes to fail but failure is an essential part of life and of learning. If your uniform isn’t dirty, you haven’t been in the game.”
9) On choosing a partner: “Remember that physical beauty is evolution’s way of assuring us that the other person doesn’t have too many intestinal parasites. Don’t get me wrong, I am all for beauty, romance, and sexual attraction –where would Hollywood and Madison Avenue be without them? But while important, those are not the only things to look for in a partner.”
“Speaking as somebody who has been happily married for 35 years, I can’t imagine any choice more consequential for a lifelong journey than the choice of a traveling companion.”
10) “Call your mom and dad once in a while:” “A time will come when you will want your own grown-up, busy, hyper-successful children to call you,” said Bernanke, who has two adult children. “Also, remember who paid your tuition to Princeton.”
The Fed chairman ended with a battle cry: “Congratulations, graduates. Give ’em hell!”
source: Princeton, CNN, Daily Stock Deals, OxBridge Research